Rochester is a city in the U.S. state of Minnesota and is the county seat of Olmsted County. Located on both banks of the Zumbro River, it is perhaps best known as the home of Mayo Clinic (giving rise to the city's nickname, "Med City") and is also home to a major IBM facility. The city has a population of 106,769 according to the 2010 US Census. making it Minnesota's third-largest city and the largest outside of the Minneapolis-St. Paul-Bloomington Metropolitan Statistical Area.